COEFFECT OF AQUEOUS SOLUBILITY OF DRUGS AND GLYCOLIDE MONOMER ON IN VITRO RELEASE RATES FROM POLY(D,L-LACTIDE-CO-GLYCOLIDE) DISCS AND POLYMER DEGRADATION

摘要

The objective of this study was to investigate the effect of aqueous solubility of model drugs and glycolide monomer (GM) from 50:50 PLGA discs on in vitro release rates and polymer degradation. 5- Flurouracil (5-FU) release was found to be increasing in proportion to drug loading amount with an initial burst for 5 days, while dexamethasone (DEX) showed absolute antithesis release profiles. However, the discs containing GM showed faster release rates than control discs (without GM), respectively and did not show lag periods during in vitro release test due to GM.