The aim of the study was formulation and in-vitro evaluation of colon specific delivery system containing Budesonide as a model drug. Core tablet consisted of Budesonide which was spray coated. Inner layer consisted of polymer combination containing HPMC and ethyl cellulose & an outer layer consisted of a pH dependent polymer, cellulose acetate phthalate. Coated tablet showed its potential for colonic drug delivery by resisting drug release after a predetermined period, which is greater than small intestinal transit time of a dosage form on the basis of in-vitro studies.
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