Novel Lactosylated Poly(ethylene glycol)–Oligodeoxynucleotide Conjugate through Acid-Labile Linkage for pH-Responsive Receptor-Targeted Oligodeoxynucleotide Delivery System

摘要

An oligodeoxynucleotide conjugated to lactosylated poly(ethylene glycol) through an acid-labile linkage (Lac-PEG-ODN) was successfully synthesized to form PIC micelles with poly(L-lysine) (PLL). The Lac-PEG-ODN/PLL PIC micelles exhibited highly antisense activity (about 65% inhibition) due to the increase in the cellular uptake and release of free ODN into cytosol. Type in text here making sure it is in a two-column format.