INTRACELLULAR CONTROL MECHANISMS OF CARDIAC CONTRACTION ENERGETICS

摘要

The regulation of cardiac muscle contraction and efficiency is based on the intracellular control of calcium kinetics and cross-bridge (Xb) cycling. Two intracellular feedback mechanisms: cooperativity and mechanical feedback allow successful description of the cardiac fiber dynamic and energetics, i.e., the force-length relationship (FLR), the force-velocity relationship (FVR) the control of relaxation and the linear relationship between energy consumption and the generated mechanical energy.