In Vitro of Self-Reinforced Composites of Highly Bioactive Glass Loaded Bioabsorbable Polymer

摘要

The aim of the study was to manufacture composites of bioabsorbable polymer P(L/DL)LA 70:30 and bioactive glass 13-93 with a high glass filler content. The effect of glass content to the degradation was investigated by studying mechanical properties and polymer matrix degradation. The mechanical properties were evaluated by 3-point bending and shearing. Polymer matrix degradation during manufacturing and in vitro was measured by gel permeation chromatography (GPC) and gas chromatography (GC). Also the water absorption (WA) and weight loss (WL) of composites were studied. The increase in glass amount was found to influence the molecular weight decrease during the extrusion but not to have an effect on the lactide monomer content of bioabsorbable polymer matrix. The mechanical properties were strongly dependent on the glass filler amount. In vitro degradation of composites was dependent on the glass content and the composite structure formed during self-reinforcing.