Molecular mechanisms associated with altered azole sensitivity in Mycosphaerella graminicola

摘要

Control of septoria leaf blotch, the most important foliar disease of winter wheat in North Western Europe, caused by the ascomycete fungus Mycosphaerella graminicola, is currently reliant on the azole (imidazole and triazole) fungicides. The dependence on azoles has prompted concerns amongst growers and the agro-chemical industry that resistance could develop, thereby compromising control of this disease. Recent studies have shown a significant decline in efficacy of some, but not all members of the class of azole fungicides, with the two azoles currently most commonly used for the control of M. graminicola, epoxiconazole and prothioconazole, still effective.