LOX-1, a lectin-like oxidized LDL receptoridentified form endothelial cells,in endothelial dysfunction

摘要

Lectin-like oxidized LDL receptor-1 (LOX-1) was initially identified as the major receptor for oxidized LDL in endothelial cells.In vitro, LOX-1 expression is induced by many inflammatory cytokines, oxidative stress, hemodynamic stimuli, and oxidized low-density lipoproteins (OxLDL).In vivo, the expression is enhanced in many proatherogenic settings including, hypertension, hyperlipidemi,and diabetes, and indeed accumulated in the atherosclerotic lesions LOX-1 activation by OxLDL causes endothelial dysfunction/injury which is characterized by the generation of reactive oxygen species (ROS), subsequently inducing monocytes adhesion to endothelial cells, and endothelial apoptosis. Besides OxLDL, LOX-1 binds multiple classes of ligands including advanced glycation end products (AGE), activated platelets, and leukocytes, which may contribute to the pathogenesis of thrombosis and inflammation related to atherosclerosis.