PPAR7 signalling and vascular cells in 2003

摘要

Peroxisome proliferator-activated receptor(gamma) (PPAR(gamma)) is a transcription factor belonging to the nuclear hormone receptor superfamily. PPAR(gamma) binds the insulin-sensitizing thiazolidinediones (TZDs) and is prominently upregulated in intimal vascular smooth muscle cells (VSMC) after mechanical injury to the vessel wall Several TZD PPAR(gamma) ligands have been shown to inhibit neointima formation.Suppression of intimal hyperplasia by PPAR7 ligands likely results from their activity to inhibit VSMC growth and to promote apoptosis. This review summarizes molecular pathways through which PPAR(gamma) regulates the expression and function of multiple cell cycle and apoptosis genes resulting in decreased VSMC proliferation and inhibition of neointima formation.