Dense Gas Antisolvent Processing of Cyclodextrins from Aqueous Solutions

摘要

In this work the feasibility of processing b-cyclodextrin (b-CD) from aqueous solutions by the Aerosol Solvent Extraction System (ASES) using carbon dioxide modified with ethanol as anti-solvent was studied. The technique is suitable for processing b-CD and water soluble drugs such as amino acids and polypeptides and minimizes residual toxic organic solvent levels in the final product. Submicron particles of b-CD were precipitated at 37°C and 160 bar. The ability to process CD systems from aqueous solutions broadens the application and significance of Dense Gas processing.