Suppressive Activity of Fexofenadine on the Production of Eotaxin and RANTES in vitro and in vivo

摘要

The influence of fexofenadine (FEX) on the production of eotaxin and RANTES was examined in vitro and in vivo. Nasal polyp fibroblasts (NPFs) were cultured with 1.0 (mu)g/ml LPS in the presence of various concentrations of FEX. After 24 h, the culture supernatants were obtained and assayed for eotaxin and RANTES by ELISA. FEX at more than 250 ng/ml could inhibit eotaxin and RANTES production. Oral administration of FEX at 60 mg, twice a day, for two weeks into pollinosis patients during Japanese cedar pollen season significantly suppressed the appearance of eotaxin and RANTES in nasal secretions.