Phomopsin Intoxication of the Rat Causes Prodigious Loss of Bodyweight and Liver Weight

摘要

Phomopsins are the toxic metabolites of the fungus Diaporthe toxica (anamorph Phomopsis sp.) that are responsible for causing the disease lupinosis (Culvenor et al., 1977). These compounds are predominantly hepatotoxic (Peterson, 1986) and in sheep cause bodyweight loss in subacute and chronic intoxications, and increased and decreased liver size in acute and chronic intoxications, respectively (Allen, 1989). An experiment was conducted to examine the effect of a single intraperitoneal injection of phomopsin A on the bodyweight and liver weight of adult female rats.