Initial SARS coronavirus genome sequence analysis using a bioinformatics platform

摘要

A dedicated anti-SARS bioinformatics web site was setup in April 2003 at the Centre of bioinformatics (CBI), Peking University (http://antisars.cbi.pku.edu.cn/). A special bioinformatics platform was constructed to analyse the sequence and structure data of SARS coronavirus and other viruses. A total file of 32 SARS coronavirus genome sequences was retrieved from GenBank and mismatches in 30 sites were revealed from the result of multiple sequence alignment. The SARS coronavirus genome sequences canbe divided into three groups based on the phylogenetic analysis using the data set constructed from the sequence mismatches.