Iron-Catalyzed Regio-and Stereoselective Ring-Opening of Oxabicyclic Alkenes with Oraganometallic Reagents

摘要

Arylative and alkenylative ring-opening reactions of a [2.2.1]-or [3.2.1]oxabicyclic alkene with a Grignard reagent take place in the presence of a catalytic amount of iron(III)chloride and a stoichiometric amount of TMEDA to produce a highly substituted 3-cyclohexen-l-ol or 3-cyclohepten-l-ol in good yield with high regio-and stereoselectivity.