Quality Control of Platelet Concentrates during Storage using different Forms of Agitation measuring the Platelet Ictiwation

摘要

In the past years prophylactic or therapeutic platelet transfusions have become a routine treatment. Therefore platelet storage prior to transfusion became necessary. One of the problems occurring during storage of platelet concentrates (PCs) is a decrease in platelet function, also known as platelet storage lesion [4]. It appears to be pronounced more with some forms of agitation of PCs during storage [1]. The platelet storage lesion is associated with an in vitro activation of platelets. The purpose of this study was to compare a new rotational storage device with the storage of PCs under routine conditions on a flat bed agitator. Quality control of PCs was performed measuring the P-selectin expression (CD62p), that is used as a predictor of platelet activation in vitro, on the platelet surface by flow cytometry [2,3].