Harmonic imaging at frequencies up to 15 MHz is now routinely used and frequencies well beyond 20 MHz are considered for diagnostic ultrasound applications. However, currently available measurement tools are not fully adequate to characterize such high frequency systems, due to the combined effects of limited frequency responses and spatial averaging. To alleviate these problems, a comprehensive wave propagation model has been developed. The model can predict the linear and nonlinear acoustic wave propagation generated by differently shaped acoustic radiators at virtually any point in the field and takes into account spatial averaging effects introduced by hydrophone probes and their associated frequency responses. The applicability of the model in hydrophone probe calibration up to 100 MHz is demonstrated. Also, a novel calibration technique termed Time-Gating Frequency Analysis (TGFA) is briefly described and calibration results in the frequency range up to 60 MHz for hydrophones having effective diameters between 150-500μm are presented. Also presented are the results of the investigation that determined the effect of using different diameters and bandwidths hydrophone probes on Pulse Intensity Integral (PII) which, in turn, affects the value of the safety indicator Thermal Index (TI). This work was supported by the NIH grant 1RO1RR16086-02.
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