Combinatorial Surface Chemistry: A Novel Concept for Langmuir and Langmuir-Blodgett Films Research

摘要

In the recent past, combinatorial chemistry has revolutionized medicinal chemistry and this approach has emerged as a powerful technique to discover novel materials. For the first time, we have attempted to combine Langmuir monolayer and combinatorial chemistry techniques to create proteinlike supramolecular structures. We synthesized a peptide lipid library and three sublibraries and studied their monolayer properties at the air-water interface. It was found that the peptide lipid libraries readily formed stable monolayers at the air-water interface and exhibited different binding activities toward carbohydrate molecules from the aqueous subphase. Our study suggests that combinatorial surface chemistry is a possible novel technique in the design and creation of artificial proteins.