Development of an in vivo model for the study of photodynamic therapy and anti-angiogenic treatments

摘要

An in vivo model has been developed for the study of photodynamic therapy (PDT) and anti-angiogenic treatments. Significant damage to the vasculature of the chick chorioallantoic membrane (CAM) was observed immediately following PDT with 5-aminolevulinic acid (ALA). Multicell human glioma spheroids were placed on the CAM at day five of embryonic development, however, neovascularization was not observed.