Because the value of karyotyping is limited by the technical problems, we studied the spectrum of chromosomal imbalances associated with pituitary adenoma using comparative genomic hybridization (CGH) and advanced computer software. In total, fifteen patients with pituitary adenomas were included in the study. The histogram of all 15 cases representing the DNA imbalances as an incidence curve along each chromosome showed losses particularly for chromosomes lp, 2q, 4, 5, 6, llq, 12q, 13q and 18q as well as overrepresentation on 9q, 16p, 17p, 49, 20q. Functioning adenomas carried more imbalances than non-functioning, specifically deletions on chromosome 4 and 18q as well as overrepresentations of chromosomes 17 and 19.
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