An ultrahigh resolution ophthalmic optical coherence tomography (OCT) system has been developed. Using a femtosecond Ti:sapphire laser light source, which generates bandwidths of ～150 nm at 800 nm, real-time, cross-sectional imaging of the retina with ～3 μm axial resolution is possible. Ultrahigh resolution OCT images of retinal morphology were obtained in normal subjects and patients with retinal disease. Intraretinal architectural morphology associated with macular diseases such as macular edema, epiretinal membranes, and macular holes can be visualized with unprecedented resolution. Ultrahigh resolution ophthalmic OCT promises to improve the early diagnosis of retinal diseases as well as enable monitoring of disease progression and the efficacy of therapeutic intervention.
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