Evaluation of HPV Testing by PreTect PV-Proofer vs. Hybrid Capture-2-Test Used in Cervical Cancer Screening

摘要

Since oncogenic human papillomavirus infection (HPV) is associated with the development of cervical intraepithelial neoplasia (CIN) and invasive cervical cancer [1], our purpose was to compare two different commercial methods: 1) the Hybrid Capture?(HC2), detecting the 14 high-risk HPV, and 2) the PreTect瓾PV-Proofer (PPT), detecting abnormal stabilized E6/E7 mRNA from 5 carcinogenic HPV types, with liquid based cytology (LBC) and his-topathology. We were looking for the added value of detecting oncogenic expression from HPV in comparison to only detecting the presence of HPV DNA. However, cytological or/and histological intervention will be necessary to differentiate between lesions that need an additional treatment or continuous control.