Long-term outcome and predictors of MACE after EPC-coated and drug eluting stent implantation

摘要

Aims. To analyze the long-term results of PCI with DES and EPC-capturing stents.Metods and results. 316 patients underwent percutaneous coronary interventions (PCI) with EPC capturing Genous stent, 2046 patients - with drug (sirolimus) eluting stents. During second year of follow-up the incidence of MACE was 16% in DES group and 14% - in Genous group. In Genous group more patients requred subsequent revascularization procedures (12%) compared to DES group (4%). In DES group diabetis mellitus and discontinuation of DAPT due to noncardiac surgery were the independent predictors of MACE. In Genous group age and long lesions became the independent predictors of MACE. In DES group in diabetic patients there was increase of C-protein level after discontinuation of dual antiplathelet therapy (DAPT). There was no response of C-protein level in Genous group after termination of DAPT. Conclusions. Patients with clopidogrel withdrawal because of the non-cardiac surgery have the worst outcome among SES-implanted patients. Long lesion is the strong predictors of MACE after EPC stent.