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TREATMENT OF PATIENTS AFTER STENT IMPLANTATION OR BALLOON DILATATION AND DRUG ELUTING STENTS
TREATMENT OF PATIENTS AFTER STENT IMPLANTATION OR BALLOON DILATATION AND DRUG ELUTING STENTS
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机译:支架植入或气囊稀释和药物洗脱支架后的患者治疗
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摘要
The present invention relates to a nucleic acid molecule for use in the treatment or preventive treatment of a patient after stent implantation or balloon dilatation, wherein the nucleic acid molecule is selected from (a) a single-stranded nucleic acid molecule comprising or consisting of the sequence of SEQ ID NO: 1, 2, 3 or 4 or a sequence having at least 90% sequence identity to the sequence of SEQ ID NO: 1, 2, 3 or 4; (b) a hairpin RNA, wherein one of the regions forming the double-stranded portion of said hairpin RNA comprises or consists of the sequence of SEQ ID NO: 1, 2, 3 or 4 or a sequence having at least 90% sequence identity to the sequence of SEQ ID NO: 1, 2, 3 or 4; (c) an at least partially double-stranded RNA comprising two separate single strands, wherein a region within one of the strands, said region being located within the double-stranded portion of said double-stranded RNA, comprises or consists of the sequence of SEQ ID NO: 1, 2, 3 or 4 or a sequence having at least 90% sequence identity to the sequence of SEQ ID NO: 1, 2, 3 or 4; (d) a nucleic acid molecule encoding the nucleic acid molecule of (a) or the RNA (b); and (e) a nucleic acid molecule or a two nucleic acid molecules encoding the two separate single strands of the RNA of (c). The present invention also relates to a drug eluting stent comprising the nucleic acid molecule according to the invention.
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机译:本发明涉及在支架植入或球囊扩张后用于治疗或预防患者的核酸分子,其中所述核酸分子选自(a)包含或由其组成的单链核酸分子。 SEQ ID NO:1、2、3或4的序列,或与SEQ ID NO:1、2、3或4的序列具有至少90%序列同一性的序列; (b)发夹RNA,其中形成所述发夹RNA的双链部分的区域之一包含SEQ ID NO:1、2、3或4的序列或由其组成或具有至少90%的序列同一性的序列SEQ ID NO:1、2、3或4的序列; (c)包含两条单独的单链的至少部分双链RNA,其中一条链中的一个区域位于所述双链RNA的双链部分内,该区域由以下序列组成或由以下序列组成: SEQ ID NO:1、2、3或4或与SEQ ID NO:1、2、3或4的序列具有至少90%序列同一性的序列; (d)编码(a)的核酸分子或RNA(b)的核酸分子; (e)编码(c)的RNA的两条分开的单链的核酸分子或两个核酸分子。本发明还涉及包含根据本发明的核酸分子的药物洗脱支架。
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