Left Ventricular Dyssynchrony Is Associated with Poor Prognosis in Heart Failure Patients Undergoing CABG

摘要

The objective of the present study was to assess the relationship between the presence of left ventricular dyssynchrony and clinical outcome in patients with moderate systolic heart failure undergoing CABG. The presence of pre-CABG dyssynchrony >=119 ms had the highest predictive accuracy for in-hospital mortality (sensitivity 84%, specificity 71%). During the median follow-up period of 359 days, post-CABG dyssynchrony >72 ms was the strongest independent predictors for deaths or hospitalizations for heart failure (HR 5.02; 95% CI 2.57-10.02, p<0.001). Patients without post-CABG dyssynchrony had excellent prognosis compared to patients with severe post-CABG dyssynchrony (event rate 10% vs. 55%, p<0.001). The role of surgical myocardial revascularization (CABG) in patients with heart failure is poorly defined. Cardiac dyssynchrony is associated with functional deterioration and poor-prognosis in advanced systolic heart failure (1). The objective of the present study was to assess the prevalence of pre- and post-CABG LV dyssynchrony and its relationship to clinical outcome in patients with stable ischemic cardiomyopathy and dyspnea as the predominant symptom.