Association between the PPARalpha-L162V polymorphism and clinical features of coronary heart disease in Russia.

摘要

Introduction. Genetic factors, alone or in interaction with other traditional risk factors, are thought to be involved in the development of the coronary heart disease (CHD).Recent data suggested that atherosclerosis is associated with immune inflammation and functional status of peroxisome proliferator-activated receptors. Peroxisome proliferator-activated receptors (PPAR) are nuclear receptors present in several organs and tissues. They are subdivided into PPAR alpha, PPAR gamma and PPAR delta. PPAR alpha and gamma are the two main categories of these receptors, which are both characterized by their ability to influence lipid metabolism, glucose homeostasis, cell proliferation, differentiation and apoptosis, as well as the inflammatory response, by transcriptional activation of target genes. That is why those receptors are the new targets of atherosclerosis prevention [1,2].