Obesity and atherosclerosis in a murine model of diabetes

摘要

The prevalence of obesity, especially among pediatric population in many countries is a real public health problem. Today obesity is considered as an inflammatory state of 'low grade', characterized by a moderate but chronic elevation of pro inflammatory adipokines secreted by white adipose tissue. In humans, recent studies show that aortic sclerosis and its progression to aortic stenosis (AS) is due to an atherosclerotic process promoted by obesity. In this study we show that Psammomys obesus (P.obesus) is atherosensible. At birth, the elastic lamellae of aortic wall are very undulating and enzyme activities limited to glycolysis and esterolysis. As in humans the arterial lesions begin very soon (4th week). In HCD P.obesus develop rapidly a systematic morbid obesity, and coronary disorders lead ineluctably to the rupture of the aneurysm of the abdominal aorta. The study of obesity and its pathological consequences shows that P.obesus is a model particularly well suited to represent these human diseases.