Clinical Implication of Ambulatory Arterial Stiffness for Patients with Coronary Artery Disease

摘要

The ambulatory arterial stifness index (AASI) was proposed as a new measure for the evaluation of arterial stiffness. Aims: to investigate whether AASI reflects arterial stiffness in patients with coronary artery disease by comparing AASI and 24h-pulse pressure (PP) with carotid-radial puls wave velocity (PWV-CR). Material and methods: we analysed 214 consecutive symptomatic patients who underwent coronary angiography. Clinical, laboratory and echocardiographyc variables, 24h-ABPM and PWV-CR (Complior SP device) were obtained. AASI was calculated as 1-the regression slope of 24-h diastolic on systolic blood pressure. Results: in all subjects AASI correlated with PWV-CR (r=0,925,p<0,001). This association was strongly significant in patients with single-vessel disease (r=0.942, p<0.001), two-vessel disease (r=0.90, p<0.001) and three-vessel disease (r=0.88, p<0.001). We found a positive correlation between AASI and 24h-PP (r=0.79, p<0.001) and mean arterial pressure (r=0.49, p<0.001). Conclusions: AASI had a significant relationship with 24h-PP in the coronary artery disease patients. The correlation with 24h-PP was stronger for AASI than for PWV-CR. AASI may improve the risk stratification based on ambulatory blood pressure monitoring.