Stereoselective Synthesis of trans-2,5-Disubstituted Tetrahydrofurans

摘要

We have shown that trans-2,5-dsubstituted tetrahydrofurans can be obtained stereochemically pure from lactol 1. Since the two enantiomers of 1 are available, this approach can be used to synthesize the two diastereomers of trans-2,5-disubstituted tetrahydrofurans stereochemically and enantiomerically pure.