Coronary Circulation in Sepsis

摘要

Septic shock is characterized by increased cardiac output and diminished systemic vascular resistance, associated with widespread alterations of the circulatory control of tissue oxygen delivery. Micro circulatory dysfunction, hyporespon-siveness of arterial vessels, and depressed myocardial function have been identified in this syndrome. Indeed, strong evidence has also accumulated for myocardial dysfunction early in septic shock, even in the presence of an elevated cardiac output. Numerous studies have investigated the myocardial function in septic shock, but few investigations have coupled it to changes in coronary circulation, and its was suggested that inadequate coronary blood flow could play a role in the precipitation of heart dysfunction.