PREDICTION OF PROTEIN RELEASE RATE FROM CROSS-LINKED BIODEGRADABLE HYDROGELS BASED ON THE GEL MESH SIZE AS DETERMINED BY NMR RELAXATION TIME

摘要

Hydrogel mesh size was determined from NMR relaxation measurements of gel polymer protons. The release rates of lysozyme, bovine serum albumin and β-galactosidase from cross-linked dextran and gelatin hydrogels could be predicted according to a mathematical model reported by Ogston using the hydrogel mesh size determined by NMR measurements.