Ligand protection strategies for contact point determination by Edman degradation of photolabeled peptide receptors

摘要

Probing G-protein coupled receptor (GPCR) structures is a priority in the functional and structural understanding of GPCR.No simple generalisations can be made for binding sites of peptides as they interact with a greater number of residues in the transmembrane domains and/or extracellular loops of their cognate receptors.