Study on struture-activity relationship of the immunosuppressory fragment of ubuquitin

摘要

Ubiquitin is a small protein (8.5 kDa) present in all eukaryotic cells,which plays an important role in tagging proteins for destruction.Our previous studies revealed that the 50-59 fragment (LEDGRTSLDY) of the ubiquitin molecule possessesunusually high immunosuppressory potency,comparable with that of cyclosporine A[1].The active sequence is located in the loop of the molecule exposed towards the sovlent and therefore may serve as an important functional epitope for intermolecular binding.