Synthesis,structural characterisation and epitope elucidation of the cytoplasmic domain of Alzheimer's amyloid precursor protein by FT-ICR mass spectrometry

摘要

APP is the precursor of amyloid beta peptide,which is the major component of amyloid plaques that characterize AD.It has been pointed out [1] that the cleavage of APP to yield amylodogenic Abeta involves a complex metabolic pathway that is mediated by intracellular targeting sequences located in the cytoplasmic tail.