Three-dimensional structure of thermolysin-linearlized microcin J25:evidence for an essential role of the 11-16 loop in microcin J25 structure and antimicrobial activity

摘要

Microcins are gene-encoded antimicrobial peptides secreted by Enterobacteriaceae.They are active against phylogenetically related bacteria and are therefore contributing to microbial competitions.They can be classified into two subgroups depending on the occurrence of posttranslational modifications on the mature peptides.