HETEROLOGOUS PROTECTION AGAINST PPE WITH ENTERISOL~(R) ILEITIS, ALC IN PIGS

摘要

Lawsonia intracellularis, an obligate intracellular bacterium, is the causative agent of porcine proliferative enteritis (PPE). PPE is an enteric disease that infects a variety of animals, most notably swine. Clinical effects of this disease are chronic weight loss, unthriftiness, diarrhea, and death. Clinical cases of PPE are observed most often in pigs' 6-20 weeks of age. The objective of this study was to determine the efficacy of a lyophilized avirulent L. intracellularis vaccine, Enterisol~(R) Ileitis ALC (Boehringer Ingelheim Vetmedica, Inc.), in pigs challenged with a virulent pure culture L. intracellularis isolate N101494 heterologous to the vaccine's parent isolate, N343.