STUDY OF THE VACCINE Ingelvac~R APP COMPOSITION

摘要

Swine pleuropneumonia is a severe and economically importantdisease of pigs which is caused by the gram-negative bacterium Actinobacitlus pleuropneumoniae (App). The clinical course of the disease can be peracute, acute subacute or chronic, dependingon the virulence of the infecting strain, the infective dose, the immune status of the infected animal and stress caused by adverse environmental conditions. The capsular polysaccharide, outer membrane proteins and lipopolysaccharide endotoxin have beenimplicated in the pathogenesis of the disease. However, antibodies directed against these cell wall components do not appear to mediate bacterial clearance from infected lungs, since formaline-treated and heat-killed bacterins, which induce antibodies tothese bacterial components, provide only minimal and serotype-specific protection against acute infection.