Robust Sliding Mode Closed-loop Glucose Control with Meal Compensation in Type 1 Diabetes Mellitus

摘要

This work addresses the design of a robust closed-loop plasma glucose controller for Type 1 Diabetes Mellitus patients. The feedback controller is based on Sliding Mode Control (SMC) while robust feedforward boluses to compensate food intake are calculated in a robust way by means of an interval glucose predictor that minimizes the risk of hypoglycaemia. The designed controller has been validated in a virtual environment following standard protocols. The resulting control algorithm shows a considerable robustness regarding intra-patient variability in insulin sensitivity as well as an enhanced ability to handle disturbance rejection. The International Diabetes Federation guidelines for glycaemia targets in Diabetes Mellitus are fulfilled by the designed control strategy.