Surface Morphology Variations of Porous Nano-Calcium Phosphate/Poly(L-Lactic Acid) Composites in PBS

摘要

Porous nano-calcium phosphate (NCP)/poly (L-lactic acid)(PLLA) composites were prepared by thermally induced phase separation method. Three kinds of NCP, α-tricalcium phosphate (α-TCP), β-tricalcium phosphate (β-TCP), and biphasic tricalcium phosphate (α/β-TCP) were used. The pore wall surface morphology variations of the porous composites after soaking in phosphate-buffered saline (PBS) with pH 7.4 at 37°C were investigated. The morphology variation was mainly related to the hydrolysis of α-TCP particles, which transformed from spherical particles to into platelike aggregates, resulting in rougher surface. The α-TCP content in NCP and soaking time are key influence factors for the variations. This finding could be used to optimize the conditions for biological processes as well as for growth factor accommodation and release.