Target Prediction of Transcription Factors: Application of Structure-Based Method to Yeast Genome

摘要

Complete genome sequences of many organisms have become available and the functional analysis of genomes will be a target of intensive research. Gene regulation in higher organisms is one of the most important biological functions, and it is achievedby a complex system of transcription factors. Transcription factors usually bind to multiple target sequences and regulate multiple genes in a complex manner. Finding target genes for transcription factors at the genome level will lay a basis for the analysis of the gene regulatory network. We have been developing methods for predicting target sequences of transcription factors. Structure-based methods, which utilize structural data of protein-DNA complexes, are promising candidates for DNA target prediction. Here we apply this method to the target prediction of transcription factors in the whole yeast genome.