METHYLGLYOXAL MODIFICATION OF HEAT-SHOCK PROTEIN 27 IN COLON MUCOSA OF HUMAN ULCERATIVE COLITIS

摘要

Patients with chronic inflammatory bowel disease (IBD) including ulcerative colitis (UC) are at increased risk of developing colorectal cancer (CRC). Indeed, IBD ranks among the top three high-risk conditions for CRC, together with familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer. CRC development in association with IBD appears to be closely relate to chronic inflammation of the large bowel mucosa . Also, IBD-associated colon carcinogenesis can be summarized as an inflammation-dysplasia-carcinoma sequence: hyperplastic lesions in the inflamed mucosa develop CRC through flat dysplasia.