Prognosis of CML Based on the Cytogenetic Abnormalities Other than t(9;22)

摘要

Cytogenetic abnormalities other than classic t(9;22) translocation are present in approximately 5-12% of patients with chronic myeloid leukaemia (CML). In 38 consecutively CML diagnosed patients, classified according to Kantajian's stages, cytogenetic studies were performed in bone marrow specimens, including: standard karyotype, G-banding techniques and fluorescence in situ hybridization (FISH). Therapeutic schedule included hydroxyurea followed by alpha-interpheron. Four patients, who underwent bone marrow transplant program, were excluded for the analysis. Clinical endpoint was the onset of both blast crisis or accelerated phase. Two groups were established according to cytogenetic findings (1: typical t(9;22) and 2: variant or complex karyotypcs). Descriptive analysis, t-test as well as cumulative survival were performed concluding that the presence of variant or complex karyotypes is related to a poorer response to treatment and worse prognosis.