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On Counting the Number of Consistent Genotype Assignments for Pedigrees

机译:关于划分百分比的一致基因型分配的数量

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Consistency checking of genotype information in pedigrees plays an important role in genetic analysis and for complex pedigrees the computational complexity is critical. We present here a detailed complexity analysis for the problem of counting the number of complete consistent genotype assignments. Our main result is a polynomial time algorithm for counting the number of complete consistent assignments for non-looping pedigrees. We further classify pedigrees according to a number of natural parameters like the number of generations, the number of children per individual and the cardinality of the set of al-leles. We show that even if we assume all these parameters as bounded by reasonably small constants, the counting problem becomes computationally hard (#P-complete) for looping pedigrees. The border line for counting problems computable in polynomial time (i.e. belonging to the class FP) and #P-hard problems is completed by showing that even for general pedigrees with unlimited number of generations and alleles but with at most one child per individual and for pedigrees with at most two generations and two children per individual the counting problem is in FP.
机译:在遗传分析和复杂的章节中,群体中基因型信息的一致性检查在遗传分析中起重要作用,并且计算复杂性是至关重要的。我们在这里展示了计算完整一致基因型分配数量的问题的详细复杂性分析。我们的主要结果是多项式时间算法,用于计算非循环键入的完整一致性分配的数量。我们进一步根据几代人数,每个人的数量和套装组的基数等待许多自然参数进行分类。我们表明,即使我们假设所有这些参数由合理的小常数所限制,计数问题也变为循环键入的计算上硬(#p-complete)。用于计数多项式时间(即属于FP)和#P-Culd问题的问题的边界线通过表明即使对于具有无限数数量的世代和等位基因,而且每个人每人大多数孩子也是如此与大多数两代和每个单独的两个孩子计数问题的少数是FP。

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