Convenient and Efficient Synthesis of N-(1-Subsituted Ethoxycarbonylmethyl) 1-Ethoxycarbonylmethyl-3- ethyl-1,2,3,4-tetrahydro-4-oxo-1 ,3,2- benzodiazaphosphorin-2-carboxamide 2-Oxides

摘要

Some novel N-(1-subsituted ethoxycarbonylmethyl) 1-ethoxycarbonylmethyl-3-ethyl-1, 2, 3, 4-tetrahydro-4-oxo-1,3, 2-benzodiazaphosphorin-2-carboxamide 2-oxides have been designed and synthesized by a convenient one-pot procedure in good yields, in which the hydrochlorides of α-amino acid esters reacted smoothly with bis (trichloromethyl) carbonate with the help of four molar equivalents of triethylamine to give the corresponding isocyanates that then formed the products by the addition with the phosphorus reagent containing a P―H bond.