Formation of Calcium-Phosphate Films with Gradient Composition on Alumina Ceramics by Spray-Pyrolysis Technique and Their Biocompatibilities by Cell-culture Tests

摘要

Calcium-phosphate films with gradient composition were formed on alumina ceramics by spray-pyrolysis technique. The crystalline phases of the resulting films were of the hydroxyapatite and tricalcium phosphate (TCP). The TCP/RAp molar ratio increased on going from the substrate side to the surface. The resulting film was porous; the pore-size distributions mainly were the ranges from 1000 to 10 #mu#m, from 10 to 1 #mu#m and submicrometers. A cell-culture test using an osteoblastic cell (MC3T3-E1) showed that the resulting porous films had excellent biocompatibilities.