Bone Bonding in Bioactive Glass Ceramics Combined with a New Synthesized Agent TAK-778

摘要

We studied the stimulatory effects of TAK-778, a new synthetic 3-benzothiepin derivative that promotes osteoblast differentiation, in bone bonding to apatite and wollastonite containing glass-ceramic (A-W GC) implants in rabbit tibiae. Smooth-surfaced rectangular plates(15 X l0 X 2mm) made of A-W GC were implanted into the proximal metaphyses of bilateral rabbit tibiae, with TAK-778-containing sustained-release microcapsules packed into the medullary cavity in one limb and untreated microcapsules packed in the contralateral limb. At four, eight, and 16 weeks after implantation, bone bonding at the bone/implant interfaces was evaluated by a detaching test and undecalcified histological examination. The tensile failure load increased from 4 to 16 weeks for both groups; however, the tensile failure load of the TAK-778-treated group was significantly greater than that of the control group at each interval after implantation. Histologically, the TAK-778-treated specimens showed greater new bone formation mainly in the medullary cavity and more extensive bonding between the implant and bone than the untreated specimens. The results of this study suggest that adding osteoinductive TAK-778 to A-W GC implants may significantlly accelerate bone apposition to the implants and improve the bonding process at the interface. This would help to establish an earlier and stronger bonding of orthopaedic ceramic implants between the surrounding bone tissue.