Bone Bonding in Bioactive Glass Ceramics Combined with a New Synthesized Agent TAK-778

摘要

ew studied the stimulatory effects of TAK-778, a new synthetic 3-benzothiep in derivative that promotes osteoblast differentiation, in bone bonding to apatite and wollastonite containing glass-ceramic (A-W Gc) implants in rabbit tibiae. Smooth- surfaced rectangular plates(15x10x2mm) made of A-W GC were implanted into the proximal metaphyses of bilateral rabbit tibiae, with TAK-778-containing sustained- release microcap sules packed into the medullary cavity in one limb and untreated microcap sules packed in the contralateral limb.