Effect of Particle Size on Bioglass Dissolution

摘要

The dissolution behaviour of melt-derived 45S5 and sol-gel derived 58S Bioglass powders produced with various particle size ranges was evaluated in this work. The powders were characterized for particle size distribution, specific surface area, porosity and textural features. Dissolution studies were carried out in simulated body fluid (SBF) and in #alpha#-MEM based culture medium, at 37 deg C under dynamic conditions (1 Hz) for periods of 30 min, 1, 2, 4, 8, 17 and 22 hours. The concentrations of elements dissolved from the glasses were evaluated using Induced Coupled Plasma analysis (ICP). The reacted powders were analysed using FTIR to observe the formation of a hydroxycarbonate layer on the surface, which gives indication of the material bioactivity. The results show that the varying the particle size distribution of bioactive glasses provides a means to control dissolution rates and rate of HCA layer formation Thereby, it can be conveniently used as a tool to obtain controlled delivery of the bioactive glass components that stimulate osteogenesis.