The effects of competition, frustration, 'anti-stress' and stress on the exocrine pancreatic secretion were studied in six pigs with chronic catheters in the pancreatic duct, duodenum and jugular vein. No effects of competition were seen. During frustration the volume of pancreatic juice increased to postprandial levels while the protein output did not rise until the pigs were actually fed. After an injection of amperozide the secretion practically ceased. Three and 4 days after an injection of ACTH, when the serum concentration of Cortisol was back down to normal, an increased output of protein and trypsin was seen.
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