Sequential Memory Recall in CA1 Taking Advantage of Theta-Like Spatiotemporal Activity of CA3: A Hippocampal Model

摘要

Sequential memory recall in a hippocampal neural network model was investigated. The hippocampus is known to be involved in, for example, associative memory, episodic memory and spatial learning. These functions require the hippocampus to store not only memory patterns but also links between them. On the other hand, rhythmic activity such as the theta-rhythm is observed in the hippocampus and relevance between higher order tasks and theta-rhythm is object of much interest. In the present study, three memory patterns were stored as steady patterns of SC connection weight. Links between these memories were stored as asymmetric recurrent synaptic connection weights in CA3. These asymmetric connections controlled the theta-like spatiotemporal activity of CA3. As a result, stored memory patterns were recalled sequentially taking advantage of theta-like activity of the CA3 network.