Structure-based design,synthesis,and surface plasmon resonance (SPR) detection of antagonists of the Grb2 SH2 domain

摘要

One of the critical intracellular signal transduction pathway involves the binding of Grb2 SH2 domain to the phosphotyrosine (pTyr) motifs on growth factors such as EGFR and erbB2,leading to downstream activation of the oncogenic Ras signaling pathway.