Solid-supported triazenes as alkylating polymers employed for the versatile derivatization of peptides

摘要

Recently,we have shown polymer-bound 1-aryl-3-alkyl-triazenes to be versatile tools for the smooth esterification of various carboxylic acids,including peptides and products of combinatorial synthesis.The triazenes are prepared in a 4-step synthesis on Merrifield resin.They react with carboxylic acids under loss of nitrogen and release of highly reactive carbenium ions forming the corresponding esters (Scheme 1).